Studies conducted at Yeditepe University have investigated the importance of various boron compounds for human health. In completed R&D/Product Development projects, sodium pentaborate pentahydrate was identified as the compound with the lowest toxicity and the highest biological significance among the inorganic borate compounds tested. Since sodium pentaborate pentahydrate is a borate derivative, it is assumed to have similar toxicological and biological mechanisms of action as boric acid and tetraborate.
*Pharma Quality: It meets the technical standards deemed suitable for use in the pharmaceutical industry.
It does not break down into metabolites.
It prevents unforeseen adverse effects by not reacting with other molecules.
It does not accumulate biologically in tissues.
It is recommended that individuals with kidney disorders seek medical evaluation.
It provides protection against oxidative stress and heavy metal toxicity.
It supports the regulation of control in the cell cycle.
It particularly aids in the restoration of DNA repair mechanisms associated with aging.
INGREDIENTS
Aqua, Butylene Glycol, Boric Acid, Poloxamer 188, Poloxamer 407, Panthenol, Carbomer, Sodium Hydroxide, Phragmites Communis Extract, Poria Cocos Extract, Pantolactone.
Dermobor® Gel Skin-Loving Boron Technology
Dermobor® Gel, with its effective formula, it nourishes, moisturizes, and protects your skin. This innovative product, set to become an essential part of your daily care routine, brings the power of the boron element to your skin.
With the scientifically proven effects of boron, we elevate skincare to a professional level. Our dermocosmetic products, suitable for all ages and skin types, offer solutions to skin concerns and redefine the concept of beauty.
Optimal Hydration Support with Hydrogel Technology:
Dermobor® Gel, A specially formulated skincare product with the rejuvenating and healing properties of boron mineral. While boron exhibits antiseptic effects on the skin, the active ingredients in Dermobor® Gel provide deep hydration, revitalize the skin, and help even out skin tone. Suitable for all ages and skin types, this product not only offers daily care but also promotes a healthy and balanced appearance for your skin.
- Provides deep hydration to your skin.
- Possesses anti-edema properties.
- Strengthens and protects the skin barrier.
- Provides skin-friendly care with natural ingredients.
USAGE RECOMMENDATION
Apply generously to the desired area where dryness is felt or where you wish to create a protective barrier, ensuring full coverage.
Gently massage the applied area to ensure absorption. Apply 1-3 times a day until the desired result is achieved. Its gel form provides ease of application. For external use only.
Dermobor® Anti-Wound
Launching Soon
A New Era in Wound Care with Boron Technology
Dermobor® is an
advanced wound care product developed by Bi7Tech, utilizing the scientifically proven
therapeutic effects of the boron element. Supported by clinical studies, the mechanism of action
of Dermobor offers a synergistic effect on processes that support wound healing, such as tissue
regeneration, antimicrobial protection, and inflammation management.
Dermobor: The New Standard of Healing
Dermobor® offers a fast and effective solution for both acute and chronic wounds, with scientifically proven effects at every stage of the healing process. Thanks to its innovative formula, it optimizes tissue regeneration, minimizes infection risks, and ensures superior results in wound care.
Patented Dermobor® formulation is specifically designed for complex wounds such as diabetic foot ulcers, pressure sores, venous and arterial ulcers, abrasions and lacerations, surgical scars, tissue graft sites, cavity wounds, and dry wound scabs.
Clinically Proven:
- %90 Recovery Rate
- % 99.9 Antiviral: Antiviral effect tested and approved
- % 99.9 Antimikrobiyal:Antibacterial (Aerobic Bacteria, Anaerobic Bacteria, Gram-Negative Bacteria, Gram-Positive Bacteria), Antifungal and Anticandidal
Stimulates Cell Proliferation
Research shows that the application of Dermobor gel formulation enhances new cell production.
Facilitates Cell Migration
Research has shown that cell migration is facilitated by the increased release of collagen type I and the production of cytoskeletal proteins.
USAGE RECOMMENDATION
Apply generously to the desired area where dryness is felt or where you wish to create a protective barrier, ensuring full coverage.
Gently massage the applied area to ensure absorption. Apply 1-3 times a day until the desired result is achieved. Its gel form provides ease of application. For external use only.
INGREDIENTS
Sodium Pentaborate Pentahydrate, Poloxamer, Carbomer, Aqua
Accelerates the production of cytoskeletal and ECM proteins. 1-4
Sodium pentaborate pentahydrate, the active ingredient in Dermobor, accelerates the healing process and strengthens the skin barrier.
Dermobor supports the production of structural proteins (collagen, elastin) and adhesion proteins (such as fibronectin, laminin) found in the cytoskeleton and ECM (Extracellular Matrix), accelerating wound closure and the regeneration of epithelial tissue and fibroblasts.
The moisture-retaining formula prevents wound drying by creating an ideal environment for regeneration. This allows the wound to close quickly while the skin gains brightness and elasticity.
Regulations of Growth Factors 2
Dermobor enhances the production of key growth factors such as TGF-β (Transforming Growth Factor Beta) and VEGF (Vascular Endothelial Growth Factor).
These factors support angiogenesis (formation of blood vessels) and extracellular matrix formation, accelerating the healing process. In the long term, they strengthen the skin barrier and promote a healthy skin structure.
Provides Broad-Spectrum Antimicrobial Protection 3
Dermobor offers broad-spectrum antimicrobial protection with its antibacterial, antifungal, and antiviral effects. Research has shown that this formulation is 99.99% effective against various pathogens. This plays a critical role in reducing infection risks, particularly in complex wounds. By reducing infection risk by 99.99%, it promotes wound healing. It accelerates the healing process without damaging the healthy tissues surrounding the wound.
1. Boron promotes streptozotocin-induced diabetic wound healing: roles in cell proliferation and migration, growth factor expression, and inflammation" DOI: 10.1016/j.bmc.2016.09.0152. Wound healing properties of boron compounds: Investigating their role in inflammation modulation and tissue repair" DOI: 10.1016/j.jwoc.2020.08.003
3. The impact of boron-based hydrogels in chronic wound management" DOI: 10.1016/j.ijwoc.2021.05.017
4. M. Benderdour, T. Van Bui, K. Hess, A. Dicko, F. Belleville, B. Dousset, Effects of boron derivatives on extracellular matrix formation, Journal of Trace Elements in Medicine and Biology, Volume 14, Issue 3, 2000, Pages 168-173, ISSN 0946-672X, https://doi.org/10.1016/S0946-672X(00)80006-1.
Effects of Dermobor on Wound Healing and Biological Mechanisms
Studies conducted at Yeditepe University demonstrated the effects of Dermobor on wound healing using acute wound models in rats under in vitro and in vivo conditions.
Cell-level studies have observed that Dermobor increases the migration rate of fibroblast cells. The boron-containing gel accelerates cell migration, aiding in the direction of dermal cells and growth factors to the wound site.
The Dermobor formulation has been shown to improve vascularization by enhancing the regeneration of blood vessels at the wound site. Histological analyses revealed that Dermobor promotes vascular growth and accelerates the healing process. Furthermore, this formulation has also expedited re-epithelialization, one of the key processes in wound healing, resulting in significant improvement in wound closure. These effects have made wound healing more efficient, particularly by supporting the organization of vascular structures.
The Dermobor formulation offers an effective alternative treatment option for wound care. This combination not only provides antibacterial activity but also accelerates wound healing by enhancing epithelial regeneration and blood vessel formation. When supported by clinical studies, this innovative formulation aims to deliver faster and more effective wound healing compared to existing treatment methods.
Sodium Pentaborate Pentahydrate (NaB) with Pluronic (Plu; F68 and F127), patented under Dermobor technology, has shown remarkable results in accelerating wound healing. In both in vitro and in vivo models, NaB significantly increased cell migration and enhanced the activities of antioxidant enzymes such as superoxide dismutase (SOD), which are critical for tissue repair.
The Dermobor formulation, by exhibiting synergistic activity, accelerated wound closure and increased collagen accumulation at the wound site. Our research also revealed that NaB and Pluronic gels enhance the expression of key growth factors such as VEGF, TGF-β, and TNF-α, which are vital for tissue regeneration.
Dermobor Gel formulation was tested using an excisional wound model in rats, demonstrating faster healing rates and superior wound contraction compared to untreated groups. Macroscopic and histopathological evaluations confirmed that wounds treated with the combination gel healed more rapidly, with increased fibroblast proliferation and collagen formation.
Dermobor Jel: Wound Healing Up to 82.46%!
82.46% Wound Closure Rate: Dermobor gel significantly reduced the open wound area in rats treated for 7 days.
Dermobor gel not only increased the wound closure rate but also supported collagen production, facilitating faster tissue repair at the wound site.
Powerful Effect Backed by Scientific Findings
Histopathological examination results obtained from the rat model reveal the effects of Dermobor gel as follows:
- Collagen Accumulation and Cell Proliferation: Rapid proliferation of fibroblasts and significant collagen accumulation were observed in the wound area of gel-treated groups.
- Rapid Epithelialization: Dermobor gel accelerated the healing process by promoting the formation of new tissue in the wound area.
Dermobor gel's proven effects demonstrate its potential use as a solution for chronic wound treatment in dermatology clinics.
Chronic Wound Healing
Acute Wound Healing
Product image and images of wounds (diabetic foot ulcers, pressure sores, venous and arterial ulcers, abrasions and lacerations, surgical scars, tissue graft sites, cavity wounds, and dry wound scabs).
Reference: Doğan A, Demirci S, Cağlayan AB, Kılıç E, Günal MY, Uslu U, Cumbul A, Sahin F. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biol Trace Elem Res. 2014 Dec;162(1-3):72-9. doi: 10.1007/s12011-014-0104-7. Epub 2014 Aug 17. PMID: 25129136.
SODIUM PENTABORATE PENTAHYDRATE AND PLURONIC CONTAINING HYDROGEL INCREASES CUTENOUS WOUND HEALING IN VITRO AND IN VIVO
Doğan A, Demirci S, Cağlayan AB, Kılıç E, Günal MY, Uslu U, Cumbul A, Sahin F. Sodium pentaborate pentahydrate and pluronic containing hydrogel increases cutaneous wound healing in vitro and in vivo. Biol Trace Elem Res. 2014 Dec;162(1-3):72-9. doi: 10.1007/s12011-014-0104-7. Epub 2014 Aug 17. PMID: 25129136.
BORON PROMOTES STREPTOZOTOCIN-INDUCED DIABETIC WOUND HEALING: ROLES IN CELL PROLIFERATION AND MIGRATION, GROWTH FACTOR EXPRESSION, AND INFLAMMATION
Demirci S, Doğan A, Aydın S, Dülger EÇ, Şahin F. Boron promotes streptozotocin-induced diabetic wound healing: roles in cell proliferation and migration, growth factor expression, and inflammation. Mol Cell Biochem. 2016 Jun;417(1-2):119-33. doi: 10.1007/s11010-016-2719-9. Epub 2016 May 20. PMID: 27206737.
THE EFFECT OF THE BORON-BASED GEL ON THE TREATMENT OF DIABETIC FOOT ULCERS: A PROSPECTIVE, RANDOMIZED CONTROLLED TRIAL
Şahin F, Pirouzpanah MB, Farshbaf-Khalili A, Ayşan E, Doğan A, Demirci S, Ostadrahimi A, Mobasseri M. The effect of the boron-based gel on the treatment of diabetic foot ulcers: A prospective, randomized controlled trial. J Trace Elem Med Biol. 2023 Sep;79:127261. doi: 10.1016/j.jtemb.2023.127261. Epub 2023 Jul 5. PMID: 37421808.
BORON AND POLOXAMER (F68 AND F126) CONTAINING HYDROGEL FORMULATION FOR BURN WOUND HEALING
Demirci S, Doğan A, Karakuş E, Halıcı Z, Topçu A, Demirci E, Sahin F. Boron and Poloxamer (F68 and F127) Containing Hydrogel Formulation for Burn Wound Healing. Biol Trace Elem Res. 2015 Nov;168(1):169-80. doi: 10.1007/s12011-015-0338-z. Epub 2015 Apr 18. PMID: 25893366.
INGREDIENTS
Sodium Pentaborate Pentahydrate, Poloxamer, Carbomer, Aqua
Dermobor® Anti-Burn Launching
Soon
Effective Solution for Radiation Burns
Dermobor® is formulated with advanced boron technology designed to provide protection against radiation effects and deliver relief.
Dermobor® Anti-Burn Gel effectively alleviates radiation therapy-induced skin burns and accelerates the healing process. Developed with boron technology, this gel is revolutionizing burn treatment.
Optimal Hydration Support with Hydrogel Technology:
Dermobor® Gel is a specially formulated skincare product with rejuvenating and healing properties, enriched with boron minerals. While boron exhibits antiseptic effects on the skin, the active ingredients in Dermobor® Gel provide deep hydration, revitalize the skin, and help even out skin tone. Suitable for all ages and skin types, this product not only offers daily skincare but also promotes a healthy and balanced appearance.
FEATURES
- Prevents radiation burns and soothes the skin.
- Accelerates cell regeneration.
- Reduces the risk of infection.
- Helps minimize skin damage caused by radiation.
- Supports the skin's natural healing process.
- Creates a protective barrier against external factors.
- Reduces discomfort, redness, and inflammation.
- Soothes and moisturizes the skin.
- Helps prevent further damage to sensitive skin.
USAGE RECOMMENDATION
Apply a thin layer to clean and dry skin.
Use immediately before and after radiotherapy sessions.
Apply a thin layer to the affected skin area 2-3 times daily or as directed by a healthcare
professional.
Dermobor Anti-Burn Gel for Radiation Therapy-Induced Burns
Clinical studies at Yeditepe University have shown that Dermobor is effective in minimizing radiation dermatitis and provides significant protective and soothing benefits. Significant improvement was observed in 85% of the patients.
Radiation dermatitis (RD) is a side effect seen in more than 90% of breast cancer patients undergoing radiotherapy (RT). This clinical study aimed to evaluate the preventive effects of a boron-based gel application on RD symptoms (dermatitis, erythema, dry desquamation, and moist desquamation) following 25 radiotherapy sessions.
The clinical study involved placebo-controlled (n = 76) and randomized intervention group (n = 181) participants aged 18-75. A gel containing 3% sodium pentaborate pentahydrate was applied 15 minutes before each radiotherapy session, while the placebo group received a gel without the active ingredient. RD symptoms were compared between the two groups.
Initially, no significant differences were found between the groups, except for body mass index (p > 0.05). After 14 days of treatment, the intervention group showed significantly lower rates of dermatitis (9.9% vs. 98.7%), erythema (12.2% vs. 96.1%), dry desquamation (3.9% vs. 50%), and moist desquamation (0.6% vs. 18.4%) compared to the placebo group (p < 0.001 for all outcomes).
The boron-based gel application significantly reduced the frequency of Radiation Dermatitis symptoms and has been shown to be a preventive treatment during radiotherapy in breast cancer patients.
The Effect of Dermobor on Burn Wound Healing
Burns are one of the most common and devastating types of wounds, often accompanied by life-threatening infections, inflammation, reduced blood vessel formation, inadequate extracellular matrix production, and a deficiency of growth factors.
Developed by Yeditepe University, Dermobor is a hydrogel formulation containing boron and Pluronic block copolymers with antibacterial properties. The effect of Dermobor was tested using cell culture techniques and an experimental burn model. The results showed that the gel formulation enhanced burn healing potential.
Key Insights from Clinical Research
- Wound Healing: The gel accelerated wound closure by enhancing fibroblast cell activity and stimulated the process of angiogenesis.
- Antimicrobial Effects: The gel exhibited strong antimicrobial effects against bacteria, yeasts, and fungi.
- Protein Expressions: The expression of proteins such as collagen, α-smooth muscle actin, transforming growth factor-β1, vimentin, and vascular endothelial growth factor significantly increased in the gel-treated group.
- Macrophage Activity: The antigen showing macrophage mobility in the burn wound highlighted the importance of migration to the wound site and the reduction of the inflammatory phase.
This study is the first research to demonstrate that boron-containing hydrogel can effectively heal burn wounds. Dermobor supports burn wound healing through complex mechanisms such as cell migration, growth factor expression, inflammatory response, and angiogenesis.
Topical agents used in the treatment of burn wounds reduce infections with products containing certain metal antimicrobials and prevent the risk of septic shock in wounds. While silver-containing products are beneficial in burn treatment, silver resistance and toxicity remain significant clinical issues. A study has shown that normal saline solution is equally effective compared to silver sulfadiazine. Additionally, in vitro toxicity analyses revealed that the doses required to overcome bacterial infection exhibited cytotoxic effects in keratinocyte and fibroblast cells.
As a solution to these issues, the development of safe and cost-effective pharmaceutical agents that can accelerate wound healing, promote rapid epithelialization, prevent bacterial infection, and support tissue regeneration is of great importance.
A new antimicrobial gel formulation containing boron and Pluronic block copolymers has been developed in the Dermobor formulation. This formulation increases dermal cell migration, growth factor expression, and vascularization in a burn wound model.
In vitro studies have shown that boron-containing gel groups increase migration speed. By enhancing the migration of keratinocyte cultures, stimulating the extracellular matrix, and supporting the acute healing of skin wounds, boron promotes effective wound recovery.
The Dermobor formulation demonstrates that the combination of Pluronics and boron enhances antimicrobial activity while also supporting the formation of vascular structures. This combination presents itself as an effective treatment alternative for burn wound care.
Dermobor has been proven to be a promising topical formulation for the effective management of burn wounds. Our studies have shown that this new treatment serves as an alternative to existing commercial products.
References: Sahin F, Pirouzpanah MB, Bijanpour H, Mohammadzadeh M, Eghdam Zamiri R, Ghasemi Jangjoo A, Nasiri B, Saboori H, Doğan A, Demirci S, Ayşan E, Çağrı Büke A, Naseri AR, Shakouri SK, Aghamohammadi D, Alizade-Harakiyan M, Seyed Nejad F. The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Oncol Res Treat. 2022;45(4):197-204. doi: 10.1159/000520363. Epub 2022 Jan 3. PMID: 34979503.Demirci S, Doğan A, Karakuş E, Halıcı Z, Topçu A, Demirci E, Sahin F. Boron and Poloxamer (F68 and F127) Containing Hydrogel Formulation for Burn Wound Healing. Biol Trace Elem Res. 2015 Nov;168(1):169-80. doi: 10.1007/s12011-015-0338-z. Epub 2015 Apr 18. PMID: 25893366.
THE PREVENTIVE EFFECTS OF BORON-BASED GEL ON RADIATION DERMATITIS IN PATIENTS BEING TREATED FOR BREAST CANCER: A PHASE III RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL.
Sahin F, Pirouzpanah MB, Bijanpour H, Mohammadzadeh M, Eghdam Zamiri R, Ghasemi Jangjoo A, Nasiri B, Saboori H, Doğan A, Demirci S, Ayşan E, Çağrı Büke A, Naseri AR, Shakouri SK, Aghamohammadi D, Alizade-Harakiyan M, Seyed Nejad F. The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Oncol Res Treat. 2022;45(4):197-204. doi: 10.1159/000520363. Epub 2022 Jan 3. PMID: 34979503.
EFFECTS OF BORON-BASED GEL ON RADIATION-INDUCED DERMATITIS IN BREAST CANCER: A DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL.
Aysan E, Idiz UO, Elmas L, Saglam EK, Akgun Z, Yucel SB. Effects of Boron-Based Gel on Radiation-Induced Dermatitis in Breast Cancer: A Double-Blind, Placebo-Controlled Trial. J Invest Surg. 2017 Jun;30(3):187-192. doi: 10.1080/08941939.2016.1232449. Epub 2016 Oct 4. PMID: 27700210.
Dermobor® P.S.O. Complex Balm
Nourishing and protective balm with natural and plant-based ingredients for skin with intense dryness.
P.S.O. Complex Balm, with its internationally patented formulation, provides antioxidant support that strengthens the skin's natural defense mechanisms. In dry skin, it helps prevent flaking and dryness by supporting the skin's ability to retain moisture.
FEATURES
- Prevents flaking and dryness.
- Strengthens the skin's moisture barrier.
- Reduces the risk of infection.
- Helps block factors that cause skin dryness.
- Provides complementary care for flaking.
- Supports the skin in gaining resilience and softness.
USAGE RECOMMENDATION
Apply to areas where you feel dryness on the skin surface. Cleanse your skin before use. Using a spatula, apply to the areas where needed. Gently massage the applied area to ensure absorption. Apply several times a day (1-3 times) until the desired result is achieved.
INGREDIENTS
Olea Europaea Fruit Oil, Black Pine Resin, Horsetail Herb, Juniper Tar
